• A. Eshiev Osh Interregional United Clinical Hospital
  • N. Taalaibekov Maxillafacial surgeon, orthodontist
  • E. Derbishev Osh State University



cleft lip and palate, risk factors, program ONYX CEPH3


The aim of the study is to examine the incidence and factors of congenital cleft lip and palate in the southern region of the Kyrgyz Republic, according to the form of clefts and according to the classification of MMDI, as well as their rehabilitation. We studied in detail the case histories of 2116 patients treated in the maxillofacial surgery department of Osh Interregional United Clinical Hospital according to the age and sex, as well as the form of congenital cleft lip and palate. Moreover, a questionnaire was administered to parents of children with CCLP for risk factors during pregnancy. A retrospective study of medical history revealed, among congenital anomalies, clefts of the soft, hard palate, alveolar process and upper lip prevailed - (combined) 891 (42,3%) Congenital cleft of soft, hard palate - 586 (27,7%), then isolated congenital cleft of the maxilla - 415 (19,6%), congenital cleft of the soft palate only 10,5% - 224 children were followed. The results of the questionnaire revealed that the parents of children born with CCLP were influenced by various unfavorable factors in the period of formation of the facial section of the fetus. The survey revealed that the relatives had CCLP, which accounted for 12.9% of all newborns, indicating a rather high role of hereditary predisposition. In addition to the hereditary genetic factor, an important role is played by infectious diseases suffered during the first trimester. It is noted that 12.8% of the children born with CCLP had infectious diseases. The mothers independently took drugs during pregnancy (antibiotics, salicylates, sulfonamides without a doctor's prescription), 17.6% of women were anemic during pregnancy, and 16.3% had severe toxemia. Along with this, it was found that the smallest number of women suffered mental trauma in the first trimester of pregnancy 0.4% of the mothers of children born with CCLP. Further, we registered patients with CCLP in the special software ONYX CEPH-3 from 01.01.2015 to the present, where we enter detailed information about patients with CCLP pathology. It creates convenience for parents both informationally and economically, as well as directly for the doctor in terms of dynamic observation of the functional and aesthetic condition and development of the child. In order to further develop programs to prevent the prevalence of congenital pathology, improve the quality of comprehensive treatment method, as well as medical and social rehabilitation of such patients and work with families of children with CCLP, we have developed a single program ONYX CEPH3 providing dispensary and rehabilitation of children.

Author Biographies

A. Eshiev , Osh Interregional United Clinical Hospital

Doctor of medical science, professor,  head of maxillafacial suregry department

N. Taalaibekov , Maxillafacial surgeon, orthodontist

Maxillafacial surgeon, orthodontist

E. Derbishev , Osh State University

Post-graduate student


Eshiev A.M. Analysis of the birth rate of children with maxillofacial pathologies in the southern region of Kyrgyzstan, the effect of actovegin and blue light on the level of postoperative complications / A.M. Yeshiev, A.K. Davydova //Young Scientist. -2013.-№12.-С.-581-583.

Eshiev A.M. Effect of organochlorine pesticides on the birth rate of children with congenital pathology in Osh region / A.M. Eshiev, E.P. Darbishev // Collection of scientific papers on the results of international scientific and practical conference. No. 4. Samara, 2017.- P. 96-99.

Eshiev A.M. Retrospective study of case histories of patients with congenital upper lip hard and soft palate potology who received inpatient treatment in Osh interregional unified clinical hospital in the period from 2013 to 2018//A. M. Yeshiev, N.T. Taalaibekov // Eurasian Scientific Association. - No. 7 (65), part 3.- 2020 - P.197-199.

Murtazaev S.M. Modern aspects of early rehabilitation of children with congenital cleft lip and palate/C.M. Murtazaev, M.E. Mahkamov, M.A. Kholmatov, A.T. Usmanov, N.E. Mahkamova //STOMATOLOGIYA. -2004.-№1.-С.-29-31.

Toichuev R. M., Abduraimova CD Content and concentration of organochlorine pesticides depending on environmental pollution in the conditions of Osh region // Actual problems of modern science: Proceedings of the 5th International Conference of Young Scientists and Students. Natural Sciences. Part 27: Medical Sciences. / / Scient. ed. Bogdanov D.V., Kolsanov A.V., Trunin A.S. -Samara: Publishing house of SamGTU, 2004.-P.-64-67.

Toichuev R.M., Zhilova L.V., Payzildaev T.R. et al. Organochlorine pesticides in placenta in Kyrgyzstan and the effect on pregnancy, childbirth, and newborn health // Environmental Science and Pollution Research. 2018. V. 25. no. 32. P. 31885. DOI:

Shatova E.A. Application in complex rehabilitation and education of children with congenital cleft lip and palate of "1C" technology / Ye.A. Shatova // Medicine and public health: materials of the VIII International scientific conference. (Krasnodar, February 2020). - Krasnodar: Novation, 2020. - С. 5-9. - URL: