PECULIARITIES OF THE CYTOKINE STATUS IN POSTOPERATIVE HYPOTHERIOSIS IN WOMEN OF REPRODUCTIVE AGE

Authors

  • M. Magomedov FSBEI HE "Dagestan State Medical University" of the Ministry of Health of Russia, Makhachkala
  • O. Osmanov SBI “City Clinical Hospital № 67”, Moscow
  • Z. Magomedova Republican interdistrict multidisciplinary hospital

Keywords:

cytokines, reproductive age, postoperative hypothyroidism, antibodies to peroxydase, thyroid gland

Abstract

Postoperative hypothyroidism occupies one of the leading places in the structure of endocrine pathology. The relevance of the topic is associated with the need to formulate common approaches for the diagnosis of postoperative complications of hypothyroidism. However, there is still no clear idea of the causes of violations of reproductive function in postoperative hypothyroidism. The aim of this research is to substantiate the role of cytokines in postoperative hypothyroidism in reproductive women. 

Materials and methods. Based on the thyroid puncture material, from 39 patients aged 25.3 ± 3.1 g with a histologically verified diagnosis of nodular goiter, prior to surgical treatment and 1.5-3 years after it, enzymelinked immunosorbent assays were performed using the “Vector” kits Best ”(Russia). Removal of thyroid preparations was subjected to histological examination. 

Results. In the postoperative period, more than 40% showed an increase in cytokines. High serum levels of TNF-α, IL-1β, IL-6 are a reliable marker of adverse course and predictors of complications of the postoperative process. The likelihood of developing postoperative autoimmune thyroiditis depends on the content of antibodies to the thyroid peroxidase before surgery and the preservation of the clinically significant tissue volume of the thyroid residue. Conclusion. In postoperative hypothyroidism, excessive production of cytokines was noted, mainly with the development of antibodies of thyroid peroxidase and lymphocytic infiltration of the thyroid residue.

References

Dedov I.I., Melnichenko G.A., Fadeev V.V. Endokrinologiya. M.: Medicina. [Dedov I.I., Melnichenko G.A., Fadeev V.V. Endokrinologiya = Endocrinology. M.: Meditsina. 2000: 508-512. (In Russ.)].

Esina M.M. Sistema reprodukcii pri gipotireoze. Arhiv akusherstva i ginekologii im.

V.F. Snegireva [Esina M.M. Reproduction system for hypothyroidism. Arkhiv akusherstva i ginekologii im.

V.F. Snegireva = Archive of Obstetrics and Gynecology by V.F. Snegirev] 2017; 4 (2): 77-83. (In Russ.)].

Simbircev A.S. Citokiny. Klassifikaciya i biologicheskie funkcii. Citokiny i vospalenie [Simbirtsev A.S. Cytokines. Classification and biological functions. Tsitokiny i vospaleniye = Cytokines and inflammation]. 2004; 3 (2): 16-22. (In Russ.)].

Hefland M., Redfem S.S. Screening for thyroid disease: an update. Annual of Internal Medicine. 1998; 129: 144-158.

Inzucchi Silvio E., Burrow Gerald N. The thyroid gland and reproduction Reproductive Endocrinology. Philadelphia: WB Saunders. 1999: 413-435.

Sherbakov V.I., Ryabichenko T.I., Skosyreva G.A. i dr. Epitelialnye kletki zhenskogo reproduktivnogo trakta kak komponent vrozhdennoj immunnoj sistemy. Citokiny i vospalenie [Shcherbakov V.I., Ryabichenko T.I., Skosyreva G.A. et al. Female reproductive tract epithelial cells as a component of the innate immune system. Tsitokiny i vospaleniye = Cytokines and inflammation]. 2016; 2: 133-139. (In Russ.)].

Perminova S.G., Ibragimova M.H., Nazarenko T.A. i dr. Besplodie i gipotireoz. Problemy zhenskogo zdorovya [Perminova S.G., Ibragimova M.Kh., Nazarenko T.A. et al. Infertility and hypothyroidism. Problemy zhenskogo zdorov'ya = Women's health issues]. 2008; 3 (2): 65-75. (In Russ.)].

Nazhmudinova D.K., Nasyrova Sh.Sh., Adhamova N.P. Vzaimosvyaz funkcionalnyh sostoyanij shitovidnoj zhelezy i reproduktivnoj sistemy u zhenshin v usloviyah jododeficita. Problemy reprodukcii [Nazhmudinova D.K., Nasyrova Sh.Sh., Adkhamova N.P. The relationship of the functional states of the thyroid gland and the reproductive system in women under conditions of iodine deficiency. Problemy reproduktsii = Reproduction problems]. 2012; 4: 31-34. (In Russ.)].

Published

2021-01-13

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