BIOPREPARATION FOR IN SITU ANTITUMOR VACCINATION

Authors

  • A. Zinchenko Institute of Microbiology of the National Academy of Sciences of Belarus
  • L. Birichevskaya Institute of Microbiology of the National Academy of Sciences of Belarus
  • A, Shchokolova Institute of Microbiology of the National Academy of Sciences of Belarus
  • P. Krasochko Institute of Microbiology of the National Academy of Sciences of Belarus
  • A. Barashkov Vitebsk Veterinary Academy

DOI:

https://doi.org/10.31618/asj.2707-9864.2021.2.45.74

Keywords:

Veterinary medicine, cats, immunotherapy, cyclic diguanosine monophosphate, , therapeutic in situ antitumor vaccine

Abstract

The present study is focused on the first attempt to use an enzymatically produced biological preparation of cyclic diguanosine monophosphate (cyclic di-GMP) for the therapy of animal cancer. Feline breast carcinoma was chosen as the test model. The preparation was administered intratumorally to induce the immunogenic death of a part of the cancer cells and thus carry out the so-called in situ antitumor vaccination. Preliminary results indicate good therapeutic prospects of studied biopreparation for animal cancer treatment.

In conclusion, the expedience of further trials of cyclic di-GMP preparation for in situ antitumor vaccination was stated. The need to supplement this mono-preparation with another immunostimulating adjuvant characterized by a mechanism of action distinct from that exhibited by cyclic di-GMP was emphasized. DNA preparation comprising the so-called immunostimulating CpG motifs was provided as an example of such compound. 

Author Biographies

A. Zinchenko, Institute of Microbiology of the National Academy of Sciences of Belarus

Professor, D.Sc. (Biology), Head of the Laboratory

L. Birichevskaya , Institute of Microbiology of the National Academy of Sciences of Belarus

Associate Professor, Ph.D. (Biology), Senior researcher  

A, Shchokolova , Institute of Microbiology of the National Academy of Sciences of Belarus

Associate Professor, Ph.D. (Biology), Senior researcher  

P. Krasochko , Institute of Microbiology of the National Academy of Sciences of Belarus

Ph.D. (Biology), Senior researcher

A. Barashkov , Vitebsk Veterinary Academy

Professor, D.Sc. (Biology and Veterinary), Head of the Department

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2021-03-19

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