ORAL THROMBOLYTIC "THROMBOVAZIM" AND COMBINED ACUTE THROMBOSISOF THE DEEP AND SUBCUTANEOUS VINES OF THE LOWER LIMBS: EXPERIENCE AND RESULTS

Authors

  • IPO FSBEI HE "Samara State Medical University" of the Ministry of Health of the Russian Federation
  • GUZ "Ulyanovsk Regional Clinical Hospital"
  • GBUZ Samara Region "Samara City Clinical Hospital No. 8"
  • Private institution educational organization of higher education "Medical University" Reaviz"

Keywords:

saphenous vein thrombosis of the lower extremities, deep vein thrombosis of the lower extremities, thrombophlebitis, conservative treatment, thrombolytic, anticoagulant

Abstract

In the article, the authors describe the experience of using the oral fibrinolytic "Thrombovazim" in the conservative treatment of acute combined thrombosis of the saphenous and deep veins of the lower extremities against the background of the use of anticoagulants, flavonoid drugs, elastic compression of the lower extremities. The results of the use of this therapy regimen in relation to the treatment of this disease without prescribing a thrombolytic agent after 1, 3 and 6 months of treatment at the outpatient stage are presented. The dynamics of recanalization of the venous bed and the dynamics of reduction of clinical manifestations of the disease were analyzed. The safety of the treatment is also assessed.

Author Biography

, IPO FSBEI HE "Samara State Medical University" of the Ministry of Health of the Russian Federation

Doctor of Medical Sciences, Professor of the Department of Surgery

References

Jorgensen G. O. The incidence of deep venous thrombosis inpatients with supericial thrombophlebitis of thelower limbs // J. Vasc. Surg. –1993. - V. 18. - P. 7073.

Murgia A. P. Surgical management of ascending saphenousthrombophlebitis / A. P. Murgia [et al. ] // Int. Angiol. –1999. - V. 18, N 4. - P. 34347.

Titon J. P. Therapeutic management of supericialvenouse thrombosis with calcsum nadroparin / J. P. Titon, D. Auger // Ann. Cardiol. 1994. V. 32. P. 397401.

Quenet S. et al. Factors predictive of venous thrombotic complications in patients with isolated superficial vein thrombosis // J. Vasc. Surg. - 2003. - V. 38, No. 5. - P. 944-949.

Bockeria L.A., Pryadko S.I., Sergeev A.V. Modern trends in the diagnosis and treatment of varicothrombophlebitis (literature review) // Bulletin of the N.N. A.N. Bakuleva RAMS. - 2008. - T. 9, No. 6. - S. 64-69.

Gaibov A.D., Sadriev O.N., Dzhurakulov E.S., Sultanov D.D. The most important aspects of diagnosis and treatment of acute varicothrombophlebitis // Bulletin of Avicenna. - 2016. - No. 3. - S. 95-103.

Kirienko AI, Matyushenko AA, Andriyashkin VV Acute thrombophlebitis. M .: Litterra, 2006; 108 c.).

Kirienko AI, Panchenko EP, Andriyashkin VV Venous thrombosis in the practice of the therapist and surgeon. Moscow: Planida, 2012.328 p.

Kirienko A.I., Matyushenko A.A.,

Andriyashkin V.V. Acute thrombophlebitis. - M .: Litter, 2006.

Krivoshchekov E. P., Elshin E. B., Migunov I. A., Romanov V. E. Combination of anticoagulant and fibrinolytic therapy in the treatment of deep vein thrombosis of the lower extremities // Materials of the All-Russian scientific conference with international participation “Innovative technologies in surgery ". Permian. 2018.No. 1.P. 78 82.

Krivoshchekov E.P. Acute venous thrombosis: diagnosis, treatment and prevention Krivoshchekov E.P., Korymasov E.A., Lysov N.A., Katorkin S.E., Study Guide Moscow, 2020 242 pp.

Krivoshchekov EP, Ways to improve recanalization of acute deep vein thrombosis of the lower extremities Krivoshchekov EP, Katorkin SE, Elshin EB. Romanov V.E. Topical issues of phlebology. 12th St. Petersburg Venous Forum (Christmas meetings). St. Petersburg, 2019, p. 75-76.

Krivoshchekov EP, Modern treatment of deep vein thrombosis of the lower extremities with a complex of oral anticoagulants and fibrinolytics. Krivoshchekov E.P., Elshin E.B., Romanov V.E. Modern medicine №2 (14) 2019 p. 113-115

Russian clinical guidelines for the diagnosis, treatment and prevention of venous thromboembolic complications (VTEC) // Phlebology. 2015.Vol. 9.No. 4.P. 1 57.

Sabadosh R.V. The role of the small saphenous vein in the development of deep vein thrombosis in acute varicothrombophlebitis of the lower extremities // Surgery News. - 2014. - T. 22, No. 2. - S. 184-190.

Saveliev V. S., Gologorsky V. A., Kirienko A. I. et al. Phlebology. Guide for Physicians / Ed. V.S.Savelyeva. - M: Medicine, 2001 .-- 664 p.

Churikov DA Ultrasound diagnosis of venous diseases: a guide for practicing doctors. 2nd ed., Rev., And add. M: Litterra, 2015.176 p.

Korsak S.I. Comparative evaluation of the effectiveness of poly- and monovalent antithrombotic therapy of deep vein thrombosis of the lower extremities // Angiology and Vascular Surgery. - 2014. - Т6, №2. - p.67-71

Shishnev A.D. Postoperative venous thromboembolic complications // Surgery - 2015. - №1. - p.17-21

Published

2021-03-19

Issue

Section

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