информационное письмоEFFECT OF CHITOSAN, PHOTOMODULATION AND PHYSICAL EXERCISES ON THE HEALING OF THE SURGICAL WOUND IN RATS
Keywords:
surgical site infection, rehabilitation, chitosan, photomodulation, physical exerciseAbstract
In an experiment on 30 white rats, the effect of the chitosan complex, photomodulation with methylineic blue and physical exercises on postoperative wound healing was studied. The animals are divided into 5 groups of 6 rats. Group 1 - intact animals. For other groups, hair was cut on the lateral surface of the abdomen and a layer-by-layer skin incision 3 cm long was performed under local anesthesia. Group 2 - rats with natural wound healing for 10 days. Animals of group 3 were daily smeared with chitosan cream, 4 groups underwent daily photomodulation of the skin surface treated with methylene blue. The fifth group of rats, along with chitosan core and photomodulation, from the third day after the operation, received low-intensity exercise on a treadmill for 30 minutes. Wound healing was recorded by determining the area of the wound by photographing and histological examination of the skin and internal organs.
Obtained results: The best wound healing according to planimetry and histological examination was reliably noted in the 5th group during the complex treatment of the surgical wound.
Conclusions: The rehabilitation complex for large surgical wounds should include early local impact on the wound of physiotherapy procedures and physical exercises.
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