POSTBIOTIC AND OTHER PROTECTIVE MOLECULES RECOGNIZING AND BINDING GLYCOCONJUGATES IN MUCOSAL ORGANS

Authors

  • V. Lakhtin G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology
  • M. Lakhtin G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology
  • V. Davydkin G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology
  • A. Melikhova G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology
  • I. Davydkin G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology
  • O. Zhilenkova G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology

DOI:

https://doi.org/10.31618/asj.2707-9864.2020.1.43.47

Keywords:

Mucosal organ, mucosal barrier, biotope, microbiocenosis, probiotic, postbiotic, lectin, glycoconjugate, antimicrobial, antiviral, synbiotic, leader microorganism, pathogen, innate immunity

Abstract

New aspects of human mucosal cavity protection systems are under consideration. On the basis of own data it was suggested that mucosal cavities function as mucosal organs. New players of mucosal organ were proposed. They included system probiotic lectins and probiotic microorganisms, and system synthetic polymeric multivalence pattern glycoconjugates. Lectins and glycoconjugates (mucin-like or imitating, antigens, polysaccharides and other high molecular mass metabolites and postbiotics) were suggested to communicate to other glycoconjugates-recognizing molecules and receptors of the human higher hierarchic protection systems.

Concept of functioning mucosal organs is supported by own proposals, strategies, approaches, methods and algorithms. The data are useful for constructing biotope ordered pro/synbiotic microbiocenoses for application in medical biotechnology.

References

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Lakhtin MV, Lakhtin VM, Afanasiev SS, Aleshkin VA, Mironov AY. Lectins and glycoconjugates in presentation of antigens and protection against pathogens. Russian Clinical Laboratory Diagnostics (Moscow) [Klinicheskaya Laboratornaya Diagnostika, (Moskva)]. 2018;63(10):619-625. DOI: http://dx.doi.org/10.18821/0869-2084-2018-63-10-619-625 [ISSN: 0869-2084 in Russian]

Lakhtin MV, Lakhtin VM, Aleshkin VA, Afanasiev SS. Lectin-dependent diversity of natural killer populations and communications against tumors and viruses. Medical Immunology (Saint Petersburg, Russia) [Meditsinskaya immunologiya (Sankt Peterburg, Rossiya)], 2019; 21(4):595-602.

DOI: https://doi.org/10.15789/1563-0625-0-0 [p-ISSN 1563-0625, e-ISSN 2313-741X]

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Published

2020-12-11

Issue

Vol. 1 No. 43 (2020)

Section

Статьи

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